In recent years, heat stroke (HS) have been reported with increasing frequency, and this trend is hard to separate from broader environmental changes, including climate change, recurrent extreme heat events, and air pollution. When people are exposed t…
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation, joint destruction, and systemic comorbidities, particularly cardiovascular disease (CVD) associated with severe dyslipidemia. The bidirectional crosstalk …
IntroductionCytokeratin−positive interstitial reticulum cell (CIRC) tumor, a subtype of fibroblastic reticular cell tumor (FRCT), is an extremely rare primary neoplasm of lymph nodes and soft tissue, with limited understanding of its clinicopathologica…
SAPHO syndrome is a rare autoimmune disorder, and the occurrence of renal involvement in this condition is even more uncommon. We report the case of a 43-year-old male patient with SAPHO syndrome, who initially presented with palmoplantar pustulosis an…
BackgroundItaconate has received attention as a key immunometabolic mediator produced by activated macrophages, linking cellular metabolism to inflammatory responses. The determinants of circulating itaconate as a cardiovascular risk marker and putativ…
Pulmonary tuberculosis (PTB) is a complex respiratory illness and a leading cause of mortality from infectious diseases globally. The regulation of the host immune response is integral to the chronic infection process of PTB. In this process, the exces…
BackgroundConventional modified National Institutes of Health (mNIH) and Armed Forces Institute of Pathology (AFIP) systems exhibit “anatomical bias” due to their development from predominantly gastric cohorts, resulting in suboptimal prognostic perfor…
Parasitic infection caused by Leishmania major in BALB/c mice is a well-established example of a chronic inflammatory disease. Although chronic inflammation in parasitic infections stems from persistent interactions between parasites and host immune ce…
Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare chronic autoinflammatory disease characterized primarily by cutaneous manifestations and osteoarticular involvement, and remains challenging to treat. Its pathogenesis i…
