BackgroundOlive pollen allergy, a leading cause of seasonal allergic rhinitis and asthma in Mediterranean regions, is becoming increasingly relevant worldwide due to the expansion of olive cultivation. Despite its significant public health impact, the …
MicroRNAs (miRNAs) are evolutionarily conserved, non-coding RNA molecules approximately 18–25 nucleotides in length that regulate gene expression at the post-transcriptional level. Their principal mechanism of action is post-transcriptional gene silenc…
Merkel cell carcinoma (MCC) is an aggressive form of skin cancer with a high mortality rate and limited therapeutic options. Approximately 80% of MCC cases are associated with Merkel cell polyomavirus (MCPyV). The Large T antigen (LTAg) and Small T ant…
Sarcopenia is a progressive skeletal muscle disorder associated with ageing and characterized by declines in muscle strength, mass and function. Increasing evidence suggests that its development is not driven solely by myofiber atrophy or impaired prot…
BackgroundOsteoarthritis (OA) is a degenerative musculoskeletal disease of multifactorial origin causing chronic disability, despite numerous treatment options for which there are no predictive biomarkers on the different endotypes. We aimed at definin…
Current osteoarthritis (OA) management remains largely symptom-directed, while the contribution of osteoporosis (OP)-related and OA-associated subchondral remodeling to disease heterogeneity remains uncertain. This review integrates macroscopic load re…
Rabies remains one of the most preventable fatal infections, yet once clinical symptoms appear, survival is exceedingly rare. This paradox cannot be explained simply by the absence of a single effective antiviral drug. In this review, we frame symptoma…
Interleukin-34 (IL-34), a ligand for the macrophage colony-stimulating factor receptor (CSF1R), plays an indispensable role in the development and homeostasis maintenance of the central nervous system (CNS). This review systematically outlines the core…
T cell exhaustion is a state of progressive functional impairment that occurs upon persistent antigenic stimulation and is a key mechanism by which chronic parasitic infections evade host immunity. As research into T cell exhaustion continues to deepen…
Anticancer therapy can eliminate immune-visible tumour cells while simultaneously imposing selective pressures that favour residual immune-evasive populations. This mini-review conceptualizes therapy-induced immunoediting as a dynamic continuum compris…
