BackgroundSepsis-associated acute kidney injury (SA-AKI) carries high morbidity and mortality, yet its pathogenesis remains incompletely understood. Emerging evidence underscores the gut-kidney axis as a critical pathway in SA-AKI development.Objective…
Gut-derived metabolites function as critical signaling intermediaries that translate environmental cues into central nervous system (CNS) responses, playing an indispensable role in the pathogenesis and trajectory of neuroimmune inflammatory disorders….
IntroductionOur laboratory and others have shown that programmed cell death receptor-ligand 1 (PD-L1) contributes to the development of shock/sepsis-induced morbidity and mortality, but its role appears to vary across organ/cell type.ObjectiveHere, we …
BackgroundImmune checkpoint inhibitors (ICIs) are widely used in lung cancer treatment; however, immune-related adverse events (irAEs) remain an important safety-related research topic. Currently, there is a lack of comprehensive bibliometric analyses …
The OX40/OX40L axis entered clinical development in atopic dermatitis with a strong biological rationale and early signs of durable activity. However, as the treatment landscape evolved, questions emerged about whether the magnitude of monotherapy bene…
IntroductionAdaptive immune activation in lymph nodes requires rare antigen-specific naïve T cells to locate antigen-bearing dendritic cells within a spatially structured stromal network. Reduced priming efficiency is typically attributed to weak T cel…
Nowadays, the management of chronic obstructive airway diseases is shifting from traditional diagnostic labels toward a precision medicine approach based on “treatable traits.” Among these, blood eosinophilia is emerging as a biomarker of type 2 (T2) i…
BackgroundBrainstem metastasis from small-cell lung cancer (SCLC) is exceedingly rare and is associated with a dismal prognosis. This study presents a case of brainstem metastasis from SCLC treated with the TMEp-CI-M platform, achieving no evidence of …
BackgroundTumor necrosis factor-α (TNF-α) inhibitors such as infliximab are widely used in autoimmune disorders. Paradoxical inflammatory reactions including systemic sarcoidosis and neurosarcoidosis are increasingly recognized but remain rare.Case pre…
ObjectiveThis study aimed to investigate the clinical features, differential treatment responses, and management strategies of encephalitis associated with anti-Kelch-like protein 11 (KLHL11) antibodies.MethodsWe report two cases of anti-KLHL11 encepha…
