IntroductionElevated levels of serum Vitamin D (VitD) and increased expression of its receptor on peripheral blood cells have been reported in individuals who have been exposed to HIV-1 yet remain seronegative (HESN). This study aimed to investigate th…
BackgroundHuman epidermal growth factor receptor-2 (HER2) alterations, including activating mutations and gene amplification, are emerging therapeutic targets in several solid tumors. Trastuzumab–deruxtecan (T-DXd), a HER2-directed antibody-drug conjug…
Sepsis has a high incidence and mortality rate, bringing about a high global burden. Recent research has demonstrated that the S100A8/A9–NETosis feedback loop is considered a central regulator of sepsis. However, few studies have integrated these eleme…
Four decades into the HIV pandemic, HIV-2 infection remains an underutilized comparative resource for HIV-1 cure research. HIV-2 is associated with lower plasma viral loads, slower CD4+ T-cell decline, and delayed disease progression in many individual…
Sepsis has a high incidence and mortality rate, bringing about a high global burden. Recent research has demonstrated that the S100A8/A9–NETosis feedback loop is considered a central regulator of sepsis. However, few studies have integrated these eleme…
BackgroundOccult breast cancer (OBC) presents with axillary lymph node (ALN) metastases without detectable primary tumor (PT) yet exhibits paradoxically favorable prognosis compared to non-occult breast cancer (non-OBC). We aimed to elucidate mechanism…
The biomass of Quillaja saponaria is a well-characterized source of triterpenic saponins, a family of amphiphilic glycosides with broad industrial and biomedical relevance. Among these, the highly purified fraction QS-21, and the related fractions QHA …
Four decades into the HIV pandemic, HIV-2 infection remains an underutilized comparative resource for HIV-1 cure research. HIV-2 is associated with lower plasma viral loads, slower CD4+ T-cell decline, and delayed disease progression in many individual…
Immunoglobulin A (IgA) is the most abundantly produced antibody in mammals, with its secretory dimeric form playing a central role in maintaining intestinal homeostasis. Although the J chain is known to be essential for IgA transcytosis, its precise ro…
