Frontiers in Immunology
BioWinfordMR: an online platform for comprehensive Mendelian randomization analysis
BackgroundMendelian randomization (MR) has become a tool for the rapid and accurate identification of genetic relationships between phenotypes. However, owing to the lack of rigorous and standard analytical tools, many MR conclusions are unreproducible…
Comprehensive evaluation of prophylactic HPV vaccines: a systematic review and meta-analysis of efficacy, safety, and immunogenicity in males and females
BackgroundHuman papillomavirus (HPV) vaccination is a cornerstone of global strategies to prevent HPV-associated malignancies; however, uncertainties persist regarding its long-term efficacy, immunogenicity, and safety across populations, vaccine formu…
CD82-associated exhausted CD8+ T cells define prognosis and immunotherapy resistance in colon cancer
The regulation of T cell exhaustion within the tumor microenvironment plays a pivotal role in shaping the immune response to cancer and determining the efficacy of immunotherapy. However, the molecular factors governing this process in colon cancer rem…
Strategies and limitations of the bat immune response to Pseudogymnoascus destructans: the causative agent of white-nose syndrome
The rapid spread of white-nose syndrome (WNS), an invasive fungal pathogen in bats caused by the psychrophilic fungus Pseudogymnoascus destructans, represents one of the most severe ongoing wildlife disease crises in North America. Since its emergence …
Antigenic assessment for the β2-glycoprotein I/Platelet factor 4 complex in thrombotic patients with antiphospholipid syndrome
ObjectiveAntiphospholipid syndrome (APS) is an autoimmune condition characterized by recurrent thrombosis, pregnancy-related complications and circulating antiphospholipid antibodies, including anti-β2-glycoprotein I (β2-GPI). Platelet factor 4 (PF4) i…
Acute gluten-induced inflammatory response highlights CCL20 as a potential biomarker for celiac disease
BackgroundDiagnosis of celiac disease (CD) remains challenging in individuals already on a gluten-free diet (GFD). Although several alternative methods have been proposed, they have limitations. Identifying inflammation-related proteins that rapidly re…
TRIM29 drives ulcerative colitis by disrupting lipid metabolism via lysosomal dysfunction: a multi-omics and experimental study
BackgroundThe pathogenesis of ulcerative colitis (UC) involves genetic susceptibility and immune dysregulation. However, a more comprehensive understanding of its underlying mechanisms is still required.MethodsWeighted correlation network analysis (WGC…
Primary antiphospholipid syndrome presenting with unilateral renal infarction and C4d-positive cortical necrosis: a case report with a pooled analysis of 24 cases
Primary antiphospholipid syndrome (APS) is an autoimmune thrombophilic disorder characterized by recurrent venous or arterial thrombosis and/or pregnancy morbidity in the presence of persistent antiphospholipid antibodies (aPL). Renal involvement in AP…
Integrin alpha L: structure, cellular functions, and emerging role in human diseases
As an integral component of Lymphocyte Function-associated Antigen 1 (LFA-1), Integrin α L is crucial for the processes of leukocyte adhesion and migration. It engages in specific interactions with Inter-Cellular Adhesion Molecules (ICAMs), thereby pla…