BackgroundColorectal cancer (CRC) development and progression are linked to genetic factors, environmental influences, and dysregulated signaling pathways.MethodsThe differentially expressed pan-apoptotic genes (CPAN_DEGs) between CRC and normal colon …
BackgroundOf the five SARS-CoV-2 variants-of-concern (VOC), Omicron shows increased transmissibility and infectivity, but lower pathogenicity. This drop in virulence was associated with an altered entry of VOC Omicron into airway epithelia by endocytos…
With the primary aim of generating antibody tools useful for diagnostic and therapeutic applications relevant to oligonucleotide-templated reactions, an scFv filamentous phage library was screened using a specific 2′-O-methyl RNA template:oligonucleoti…
Sepsis-associated acute liver injury (SALI) results from dysregulated systemic immune responses, ultimately leading to liver dysfunction. Buddleoside (Bud), a naturally derived compound, has exhibited considerable therapeutic potential for liver diseas…
BackgroundColorectal cancer (CRC) outcomes remain heterogeneous despite therapeutic advances, posing challenges to precise prognostic stratification. Post-translational modifications (PTMs) critically regulate protein function, tumor microenvironment (…
We present an instructive case of an elderly woman with a history of diabetes and diabetic retinopathy who was admitted due to rapidly progressive renal failure requiring dialysis. Although diabetic nephropathy was initially suspected, the patient’s ra…
The pathogenesis of neurodegenerative diseases (NDDs), including Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS), is complex and multifactorial. Recent studies indicate that the microbiota-gut-brain axis (MGB…
IntroductionIL-17 is a key cytokine helping preserve the intestinal barrier against infections; however, the T cells that primarily secrete IL-17 (Th17) can promote the development of autoimmunity. In Type 1 diabetes, the role of IL-17 is less well und…
BackgroundEpstein–Barr virus (EBV) infection is frequently observed in patients with severe fever with thrombocytopenia syndrome (SFTS), yet its clinical significance remains unclear. This study aimed to characterize the impact of EBV infection on clin…
BackgroundPatients with liver cirrhosis may show minimal hepatic encephalopathy (MHE) triggered by a shift in peripheral inflammation. A main mechanism by which peripheral alterations are transmitted to the brain is the infiltration of extracellular ve…
