Epigenetic regulators alter chromatin to control transcription in response to pathogens. Histone acetylation influences DNA accessibility and gene expression, impacting latent and active tuberculosis (TB). Mycobacterium tuberculosis (MTB) requires spec…
BackgroundMicroglial neuroinflammation contributes to the progression of neurodegenerative diseases, yet it remains challenging to attenuate inflammatory responses while preserving cellular function. The effects of (R)-nicotine, diosmetin, their combin…
BackgroundAnti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis often requires intensive care and rapid escalation of immunotherapy. We report a critically ill woman with refractory anti-NMDAR encephalitis treated with tocilizumab (TCZ) as early…
Anti-CD38 monoclonal antibodies have become a central immunotherapeutic platform in multiple myeloma, where they have reshaped treatment across relapsed or refractory disease, frontline therapy, maintenance intensification, and minimal residual disease…
Leishmaniases are a group of neglected tropical diseases caused by Leishmania parasites which virulence mainly relies on its modulation of the host immune response. Neutrophils, the first recruited innate immune cells at the site of infection, are key …
Psoriasis is a chronic, recurrent, immune-mediated inflammatory skin disease in which the TNF/IL-23/IL-17 axis plays a central role in the maintenance of mature plaques. However, this classical framework does not fully explain the early immune events t…
Chronic rhinosinusitis with nasal polyps (CRSwNP) presents three persistent clinical enigmas that conventional immunological frameworks have failed to resolve. These include the paradox of locally elevated specific IgE in the absence of systemic sensit…
Comprehensive immune profiling is essential for immunomonitoring studies aimed at identification of diagnostic and prognostic biomarkers. Peripheral blood mononuclear cells (PBMCs) undergo phenotypic and functional changes during disease, making them i…
BackgroundInsomnia is a prevalent sleep disorder that strongly affects one’s quality of life and physical well-being. Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the intestines, and a majority of IBD patients suffer from com…
Rheumatoid arthritis (RA) is a chronic inflammatory disease driven by immune dysregulation, in which genetic susceptibility and environmental exposures promote persistent synovitis, progressive joint damage, and systemic comorbidities. Recent epigenomi…
