BackgroundChildhood adversity is increasingly recognized as an important early-life psychosocial exposure that may shape long-term immune function and contribute to autoimmune diseases through chronic stress, neuroendocrine dysregulation, and inflammat…
IntroductionLong-term humoral immunity to Plasmodium vivax remains poorly understood, particularly the mechanisms sustaining persistent antibody responses to Duffy Binding Protein region II (DBPII), a key vaccine candidate. Here, a 15-year follow-up st…
BackgroundThe ubiquitous tire-derived pollutant 6PPD-quinone (6PPD-Q) poses potential systemic health risks, yet its toxicological impact on the intestinal tract, particularly in the context of ulcerative colitis (UC), remains largely unknown. This stu…
IntroductionOvarian cancer (OC) is a biologically heterogeneous malignancy associated with poor clinical outcomes. Oncolytic viruses (OVs) have emerged as a promising immunotherapeutic strategy; however, optimal approaches to maximize their antitumor e…
Type I interferonopathies (TI-IFN) represent a heterogeneous group of autoinflammatory disorders characterized by upregulated type I interferon (IFN) signaling. Among them, STING-associated vasculopathy with onset in infancy (SAVI) is a rare, severe au…
IntroductionNeutrophil extracellular traps (NETs) are chromatin-based structures released by activated neutrophils that are associated with microvascular thrombosis and pulmonary inflammation. These are adverse effects that are relevant in ECMO-associa…
BackgroundBispecific antibodies (BsAbs) have emerged as a promising strategy for solid tumor treatment, yet their comparative efficacy and safety versus other antitumor therapies remain unclear.Materials and methodsLiterature was systematically searche…
Although mRNA-based COVID-19 vaccines have demonstrated high efficacy, their widespread global use remains constrained by high production costs and cold-chain requirements. Modified vaccinia virus Ankara (MVA) is a highly attenuated and thermostable vi…
Acute respiratory distress syndrome (ARDS) may remain regionally permeable and poorly reparative after the initiating insult has weakened. We propose that, in a biologically enriched subset of non-resolving ARDS, repeated entry of circulating apolipopr…
BackgroundSmall bowel metastasis from primary esophageal carcinoma is a rare occurrence, typically indicative of advanced disease and often presenting with non-specific abdominal symptoms. Failure to consider this possibility in the differential diagno…
