Colorectal cancer (CRC) develops within a mucosal ecosystem in which epithelial barrier function, colonizing microbes, inflammatory signaling, and immune cell composition are closely interdependent. Immune checkpoint inhibitors have significantly alter…
Background and aimsInflammatory stimuli drive metabolic reprogramming in macrophages, supplying energy, reducing equivalents, and methyl donors required for the production of inflammatory mediators such as IL-1β; however, metabolic strategies to regula…
BackgroundLipoprotein(a) [Lp(a)] is synthesized mainly in the liver, whereas blood cell-derived inflammatory indices reflect systemic immune–inflammatory status. We examined their associations with FibroTouch-assessed hepatic steatosis and liver stiffn…
BackgroundRashes in patients treated with epidermal growth factor receptor inhibitors (EGFRIs) are closely related to better clinical outcomes. Multiple randomized controlled trials have evaluated rashes caused by EGFRIs. We conducted a meta-analysis o…
Combined Allergic Rhinitis and Asthma Syndrome (CARAS) in children is a chronic airway inflammatory disorder with a high prevalence in childhood. In recent years, a growing body of studies has identified a close association between fractional exhaled n…
One phenotype of cerebral cortical encephalitis in myelin oligodendrocyte glycoprotein (MOG) antibody–associated disease (MOGAD) is FLAMES (fluid-attenuated inversion recovery-hyperintense lesions in anti-MOG-associated encephalitis with seizures). FLA…
The gut microbiota and natural killer (NK) cells jointly shape colorectal cancer (CRC) progression and immunotherapy response, yet existing reviews largely adopt a linear, pathogen-centric view that overlooks NK-cell heterogeneity and spatial tumor mic…
BackgroundThe Toll/interleukin-1 receptor domain-containing adaptor protein (TIRAP) is a key adaptor in Toll-like receptor signaling, classically functioning as a cytoplasmic bridging adaptor for Myeloid differentiation primary response 88 (MyD88) recr…
