Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE). The nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome plays a central role in the pathogenesis of LN. Aberr…
Cervical cancer, a human papillomavirus (HPV) -driven malignancy with inherent viral antigenicity, serves as a key model in immuno-oncology. Yet, the variable efficacy of immune checkpoint inhibitors highlights a critical gap: the lack of preclinical m…
Glucocorticoids remain among the most widely prescribed immunosuppressive and anti-inflammatory agents worldwide, yet their clinical use is complicated by substantial inter-individual variability in both therapeutic response and adverse effects. Despit…
BackgroundCoronavirus Disease 2019 (COVID-19) can cause severe clinical outcomes by triggering an excessive immune response and systemic inflammation. As disease severity increases, levels of key inflammatory markers rise accordingly. Inflammation is a…
Microbial infections rarely consist of free-floating cells. Instead, pathogens and immune cells are typically organized into complex three-dimensional (3D) structures, including biofilms, abscesses, and granulomas, which can serve to constrain pathogen…
Seasonal influenza vaccines provide variable protection against antigenically drifted influenza A (H1N1 and H3N2) and influenza B viruses. Broadly protective approaches using computationally optimized broadly reactive antigens (COBRAs) can enhance immu…
Diffuse gliomas are now diagnosed and studied through integrated molecular classification, radiomics, single-cell biology, spatial profiling, proteogenomics, metabolomics, and artificial intelligence. Yet many precision-medicine models still begin at d…
IntroductionDespite significant interindividual susceptibility to COVID-19, the molecular basis of host vulnerability in the Chinese population remains poorly defined.MethodsLeveraging the large-scale Omicron exposure following China’s transition from …
CD19-directed chimeric antigen receptor (CAR) T-cell therapy has transformed the treatment of relapsed or refractory large B-cell lymphoma (LBCL), including diffuse large B-cell lymphoma (DLBCL), yet primary resistance and relapse remain frequent. Clin…
BackgroundHead and neck squamous cell carcinoma (HNSCC) comprises biologically diverse tumors, and durable responses to immune-checkpoint blockade are achieved by only a subset of patients. There remains a need for markers that connect clinical outcome…
