BackgroundPrimary Antiphospholipid Syndrome (PAPS) is a systemic autoimmune disorder characterized by arterial and/or venous thrombosis and obstetric morbidity. Arterial thrombosis, although less frequent than venous events, is associated with substant…
BackgroundThis study aimed to investigate the clinical, serological and myopathological features of Chinese patients with inclusion body myositis (IBM).MethodsThis study retrospectively recruited patients diagnosed with IBM according to the 2024 Europe…
IntroductionSjögren’s disease (SjD) is the second most prevalent rheumatic disease and is characterized by autoimmune pathology targeting the tear-producing lacrimal glands, leading to chronic ocular surface disease. Despite important advances, lacrima…
IntroductionChemotherapy remains the standard of care for metastatic soft tissue sarcoma (STS), but clinical benefit is modest. Immune checkpoint inhibitors (ICIs), such as anti-programmed cell death 1 (PD-1) and anti-cytotoxic T-lymphocyte antigen 4 (…
ObjectiveThrombotic primary antiphospholipid syndrome (PAPS) pathogenesis remains undefined, and recurrent thrombosis may occur despite adequate anticoagulation treatment. Identifying disease-specific molecular pathways and regulators can help in the d…
BackgroundArctigenin (AG), a natural lignan compound, has been reported to reveal its anti-inflammatory effects in glucose, lipid metabolism and type 2 diabetes mellitus. An increasing number of studies suggest that microglia activation evoked neuroinf…
PurposeThe aim of this study was to present a case of early-onset mevalonic aciduria (MA) in a neonate and summarize the relevant phenotypic and genotypic spectra of MA.Methods and resultsWe describe a neonate who presented with elevated inflammatory m…
