Stromal cells are important bone marrow (BM) niche components that regulate immune cell homeostasis through the production of cytokines such as interleukin 15 (IL-15). Although stromal-derived IL-15 is known to support lymphocyte survival, it remains u…
Pegylated interferon α-2b (peg IFNα-2b) is a first-line clinical drug for the treatment of chronic hepatitis B (CHB). It can effectively reduce HBsAg levels, improve clinical cure rates, and lower the incidence of HBV-associated hepatocellular carcinom…
Lung cancer continues to be the leading cause of cancer-related mortality worldwide, accounting for more deaths than breast, colorectal, and prostate cancers combined. Over the past decade, the introduction of immunotherapy has reshaped treatment parad…
BackgroundThe mechanisms underlying the progression of chronic inflammatory arthritis remain largely unclear.MethodsWe used single-cell mass cytometry on peripheral blood from patients with active rheumatoid arthritis (RA; n=11), psoriatic arthritis (P…
IntroductionChimeric antigen receptor (CAR) T cells show limited efficacy in solid tumors. Oncolytic viruses (OVs), especially those expressing immunomodulatory cytokines like interleukin-12 (IL-12), potentiate to synergize with CAR-T therapy.MethodsWe…
Respiratory viruses impose a substantial health burden worldwide, with viral internalization into host cells being the initial step for infection establishment. This process is tightly regulated by the host cellular machinery through two major pathways…
IntroductionType 2 diabetes mellitus (T2D) is a metabolic disorder characterized by chronic hyperglycemia, insulin resistance, and meta-inflammation, which significantly compromise tissue regeneration. Although macrophage dysfunction is implicated in i…
BackgroundMaternal anti-Ro/SSA (Sjögren’s syndrome-related antigen A) [± anti–La/SSB (Sjögren’s syndrome type B antigen)] antibodies can lead to neonatal lupus, which may present most severely as autoimmune congenital atrioventricular block (CAVB). Alt…
