Rectal cancer exhibits prominent anatomical and molecular heterogeneity, shaping a tumor microenvironment that determines responsiveness to immune checkpoint inhibitors (ICIs). Though ICIs exert robust anti-tumor effects on dMMR/MSI-H rectal tumors, ov…
Basophils develop in the bone marrow and are associated with allergic inflammation but also contribute to protective immune responses against pathogens. Upon activation, they produce large amounts of cytokines, including interleukin (IL)-4 and IL-13. H…
Colorectal cancer liver metastasis is the most frequent and clinically important pattern of distant spread in colorectal cancer and remains a major determinant of poor prognosis and treatment failure. In the era of immunotherapy, liver metastasis has e…
Anti–metabotropic glutamate receptor 1 (mGluR1) encephalitis is a rare form of autoimmune encephalitis that typically presents with cerebellar dysfunction. Predominant brainstem involvement has seldom been reported. We report an 87-year-old man who pre…
BackgroundThymoma-associated myasthenia gravis is a distinct clinicopathological setting in which thymic epithelial tumor biology, autoimmunity, and perioperative neurological risk overlap. In selected hypervascular thymomas, preoperative transarterial…
Chronic obstructive pulmonary disease (COPD) is a heterogeneous syndrome characterized by persistent oxidative stress and maladaptive immune responses, rather than a single disease entity. Oxidative stress not only damages lung tissue but also reprogra…
ObjectiveMori Cortex Radicis (MCR) is an important Chinese herbal medicine with antitussive, anti-inflammatory, and analgesic effects. It is abundant in resources and low in cost, but its application in the control of fish pathogens has been insufficie…
BackgroundThe major birch pollen allergen Bet v 1 primarily affects the nose and eyes of allergic patients. After crossing the epithelial barrier, it causes IgE-mediated effector cell release, triggering inflammatory responses. We sought to develop bis…
BackgroundShort-term mycophenolic acid (MPA) withdrawal is common in kidney transplant recipients with severe infections and was extended during the COVID-19 pandemic to improve vaccine immunogenicity, yet its effects on immune cell dynamics remain mec…
IntroductionPulmonary sarcoidosis exhibits heterogeneous clinical trajectories ranging from self-limited disease resolution to chronic progressive fibrosis, yet reliable biomarkers capable of distinguishing these disease patterns remain lacking. Whethe…
