BackgroundImmune checkpoint inhibitors (ICIs) have transformed cancer outcomes across multiple malignancies. However, emerging evidence suggests that thrombotic events, including venous thromboembolism (VTE) and arterial thromboembolism (ATE) are serio…
Sjögren’s syndrome (SS) is a systemic autoimmune disorder whose precise pathogenic mechanisms remain to be fully elucidated. Although Western medicine treatment has definite efficacy, it has disadvantages such as long medication cycles and many adverse…
BackgroundClassic juvenile pityriasis rubra pilaris (PRP) (Griffiths type III) is a rare inflammatory papulosquamous dermatosis that is often refractory to conventional topical and systemic treatments. Despite the growing use of tumor necrosis factor-α…
Editorial on the research topicNext-Generation Treatment for Pediatric Cancer: Advancing Immunotherapy through Combinations. Cancer remains one of the leading causes of disease-related mortality among children and adolescents. Despite advances in treat…
BackgroundIL-17-producing Type 17 T (T17) cells are central drivers of inflammation in both psoriasis and hidradenitis suppurativa (HS), as evidenced by the clinical efficacy of IL-17-targeting therapies. However, therapeutic responses differ substanti…
Esophageal cancer is a highly aggressive malignancy with a notoriously poor prognosis. While immunotherapy, particularly immune checkpoint blockade (ICB), has revolutionized oncology, its clinical efficacy in esophageal cancer is severely limited by pr…
BackgroundRapidly progressive pneumoconiosis (RPP) is an aggressive subtype of pneumoconiosis characterized by persistent pulmonary inflammation, rapidly progressive fibrosis, and early-onset progressive massive fibrosis. However, the systemic molecula…
As a complex airway inflammatory disease, the pathogenesis of asthma is closely associated with dynamic changes in the lung microbiome and immune regulation. Asthmatic patients with distinct inflammatory phenotypes exhibit significant alterations in th…
IntroductionSmoking is the first recognized modifiable risk factor for IgG4-related disease (IgG4-RD) and a driver of rheumatoid arthritis (RA)-associated interstitial lung disease, yet whether it is associated with IgG4-positive cell infiltration in R…
IntroductionThe interplay between host immunity and the microbiome is increasingly recognized as an important factor in ocular surface diseases. Although cutaneous and intestinal dysbiosis have been implicated in atopic dermatitis (AD), the role of the…
