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Extracellular vesicles decoying across host immunity​Jorge J Canas on 3 de December de 2025 at 11:00

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J Leukoc Biol. 2025 Dec 3:qiaf173. doi: 10.1093/jleuko/qiaf173. Online ahead of print. ABSTRACT Extracellular vesicles (EVs) are essential components for intercellular communication, bioactive cargo trafficking, and homeostasis maintenance. The knowledge regarding the diverse functions and applications of EVs has continually expanded over the recent decade. The classification of eukaryotic EVs based on their biophysical or … Read more

Glycolytic diversity drives immune complexity in cancer. Cai-Yuan Wu

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Trends Immunol. 2025 Dec 1:S1471-4906(25)00285-6. doi: 10.1016/j.it.2025.11.002. Online ahead of print. ABSTRACT The interaction between the tumor immune microenvironment (TIME) and the tumor determines whether immune evasion or antitumor immunity prevails. Metabolic reprogramming is increasingly recognized as a critical factor shaping the tumor immune response. Glucose metabolism regulates the intrinsic cellular states of both immune … Read more

Auguries of adaptivity: LES γδ TCR ligand recognition revisited. Juliet L Gunn

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Trends Immunol. 2025 Dec 1:S1471-4906(25)00250-9. doi: 10.1016/j.it.2025.10.006. Online ahead of print. ABSTRACT Identification of antigenic ligands for the γδ T cell receptor (TCR) has remained a highly challenging goal since the emergence in the 1980s of γδ T cells as a distinct immune compartment. In a significant advance more than 12 years ago, endothelial protein … Read more

An mRNA platform to create isolated, monospecific Th1 responses

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J Immunol. 2025 Dec 2:vkaf318. doi: 10.1093/jimmun/vkaf318. Online ahead of print. ABSTRACT Helper T cells (CD4 T cells) are lynchpins of adaptive immune responses. Each CD4 T cell expresses a single T-cell receptor, recognizing an epitope presented by major histocompatibility complex class II (MHC-II). Due to the enormous diversity of the T-cell repertoire, it is … Read more

The Pleiotropic Roles of Cytokines in Chimeric Antigen Receptor T-cell Therapy

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Cancer Immunol Res. 2025 Dec 1:OF1-OF12. doi: 10.1158/2326-6066.CIR-25-0631. Online ahead of print. ABSTRACT Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment of cancer. However, the durable response to this therapy remains low, and there is a risk of moderate-to-severe toxicities following treatment that requires close monitoring. Over the past decade, we have learned … Read more

NK cells undergo transcriptional and functional reprogramming following Streptococcus pneumoniae infection. Júlia Torné

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Mucosal Immunol. 2025 Nov 28:S1933-0219(25)00129-1. doi: 10.1016/j.mucimm.2025.11.012. Online ahead of print. ABSTRACT Natural Killer (NK) cells are cytotoxic lymphocytes and key mediators of innate immunity, essential for combating viral infections and cancer. Notably, they exhibit immunological memory, generating a stronger response upon re-exposure to the same stimulus. While NK cell memory holds promise for infection … Read more

IL-1 family members as regulators of lymphoid type-2 immunity in cancer. Stefania Roma

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Semin Immunol. 2025 Nov 28;81:102005. doi: 10.1016/j.smim.2025.102005. Online ahead of print. ABSTRACT IL-1 family members, such as IL-1 and IL-33, are present in the tumor microenvironment and exert tumor-intrinsic and tumor-extrinsic functions with both pro- and anti-tumor effects. Among their immunoregulatory roles, both cytokines contribute to lymphoid type-2 immunity. IL-1 can indirectly promote CD4+ Th2 … Read more

ILC3s mediate intestinal immune-epithelial interactions via TGF-β1 activation. Diana Coman

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Mucosal Immunol. 2025 Nov 27:S1933-0219(25)00130-8. doi: 10.1016/j.mucimm.2025.11.013. Online ahead of print. ABSTRACT Inflammatory Bowel Disease (IBD) is a chronic inflammatory condition affecting the gastrointestinal tract. It is characterised by epithelial and immunological dysfunctions, including alterations in populations of Innate Lymphoid Cells (ILCs), including tissue-resident RORγt-expressing Group 3 ILCs (ILC3s). ILC3s contribute to the maintenance of … Read more

C3-CD18-VATPase-ATG16L1 and C3-ATG16L1 axes restrict the escape of microbes through the autophagy-lysosome pathway

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J Immunol. 2025 Nov 29:vkaf290. doi: 10.1093/jimmun/vkaf290. Online ahead of print. ABSTRACT As the key component of the complement system, C3 plays important roles in complement activation to regulate phagocytosis, lyse cells, mediate inflammation, and clear immune complexes. In the present study, CgC3 in the cell-free hemolymph of the Pacific oyster Crassostrea gigas was found … Read more

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