Nature Reviews Immunology, Published online: 16 September 2026; doi:10.1038/s41577-026-01356-5The formation of tertiary lymphoid structures (TLSs) has been associated with better outcomes in patients with certain tumours. Here the auth…
ObjectiveThis study aims to overcome the limitations of current treatments for temporomandibular joint osteoarthritis (TMJOA), which often fail to promote cartilage regeneration and necessitate repeated administrations. To this end, an injectable intel…
Acute pancreatitis (AP) is a sterile inflammatory disease initiated by acinar cell stress and amplified through innate immune, vascular, and inter-organ responses, yet effective disease-modifying therapies remain unavailable. Although premature digesti…
Adoptive T cell transfer remains a fundamental technique for dissecting the molecular mechanisms governing T cell differentiation. A successful adoptive-transfer experiment typically relies on labor-intensive construction of specific congenic mouse str…
Tumor progression is driven by metabolic remodeling that generates a microenvironment characterized by nutrient deprivation, hypoxia, lactate accumulation, lipid dysregulation, and oxidative stress. These conditions affect innate immune populations, in…
BackgroundDifferentiating papillary thyroid carcinoma (PTC) from benign nodules in patients with Hashimoto’s thyroiditis (HT) remains a significant clinical challenge due to the complex sonographic background and overlapping inflammatory features. This…
IntroductionAllogeneic hematopoietic stem cell transplantation (HSCT) in children remains challenged by chronic graft-versus-host-disease (cGvHD), significantly affecting morbidity and survival. While aberrant peripheral B-cell reconstitution has been …
BackgroundGlioma, the most prevalent and aggressive primary malignant brain tumor, is associated with poor clinical outcomes. There is an urgent need for novel biomarkers to predict survival and therapeutic response, as existing markers offer limited p…
Parkinson’s disease (PD) is a progressive neurodegenerative disorder whose pathogenesis involves complex interactions between metabolic dysfunction and neuroinflammation. The role of cuproptosis, a newly defined copper-dependent cell death pathway that…
BackgroundSevere abdominal Henoch-Schönlein purpura (HSP) can cause intense abdominal pain and gastrointestinal bleeding. Glucocorticoid therapy has limited efficacy and a high relapse rate after withdrawal. Telitacicept blocks BLyS/APRIL and inhibits …
