IntroductionCutaneous squamous cell carcinoma (cSCC) is a common keratinocyte-derived malignancy whose progression is strongly influenced by the tumor microenvironment. Although recent studies have begun to describe cellular diversity in squamous cell …
Obesity-driven type 2 diabetes mellitus is sustained by chronic low-grade sterile inflammation. The intercellular mechanisms underlying this self-amplifying state remain incompletely defined. Extracellular vesicles and neutrophil extracellular traps ha…
BackgroundEndotoxin-driven intestinal inflammation represents a major contributor to impaired barrier function, metabolic inefficiency, and immune dysregulation in both human and animal health. Strategies that reduce luminal inflammatory triggers rathe…
Cancer immunotherapy has transformed oncology, yet durable benefits remain limited to a subset of patients, and those cases are incompletely explained by tumor-intrinsic biomarkers alone. Growing evidence indicates that the host immune state is a criti…
BackgroundThis study investigated the clinical and electrodiagnostic features of vasculitic peripheral neuropathy (VPN) in symptomatic patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV) who underwent nerve conduction studies …
Asthma affects approximately 260 million people globally and causes an estimated 450,000 deaths annually, posing a serious threat to human health and life quality. Current mainstay pharmacotherapies are effective for symptom control but are associated …
The aorta is one of the major arterial vessels in the human body, serving as the principal conduit for the high-velocity blood ejected from the heart. For a long time, its function was largely understood in this limited hemodynamic context. However, wi…
Immunoglobulin light chain (AL) amyloidosis and POEMS syndrome are plasma cell proliferative disorders involving multiple organs and tissues, often presenting with nonspecific clinical manifestations. The co-occurrence of both conditions in a single pa…
The rapid rise of antimicrobial resistance (AMR) has renewed interest in bacteriophages as precision antibacterial agents that can selectively target pathogenic bacteria while limiting disruption of commensal microbiota. However, therapeutic phages are…
The therapeutic landscape of advanced melanoma has been transformed by immune checkpoint inhibitors (ICIs); however, primary and acquired resistance remain formidable challenges for a substantial subset of patients. Emerging evidence identifies the CD7…
