Inflammatory bowel diseases (IBDs) arise from a breakdown in tolerance to intestinal microbiota and are characterized by exacerbated inflammatory responses. Epithelial cells of the gastrointestinal tract play a central role in maintaining barrier integ…
IntroductionMalaria is a leading health problem with high disease burden and mortality rates worldwide. Currently approved vaccines target the sporozoite form of Plasmodium falciparum that initially infects the liver, but only provide modest protection…
Postmenopausal osteoporosis(PMOP)is a common metabolic bone disease characterized by an imbalance in bone remodeling due to estrogen deficiency. Increasing evidence suggests that alterations in gut microbiota, intestinal barrier, immune response, micro…
BackgroundPuerarin is a bioactive isoflavone with reported anti-tumor and immunomodulatory activities; however, its candidate molecular targets and associations with the immune microenvironment in lung adenocarcinoma(LUAD) remain incompletely defined. …
Neuroimmune diseases comprise a heterogeneous group of disorders in which B cells, plasmablasts, plasma cells, autoantibodies, and T cells contribute differently to tissue injury. Although B-cell-directed biologics have improved disease control, some p…
BackgroundNon-union formation is one of the major complications in trauma and orthopedic surgery. The inflammatory response at the fracture site is crucial for determining the healing outcome. However, there is limited information on the expression pro…
Metal ions, as common endogenous signaling molecules, play a crucial role in immune homeostasis and inflammation regulation. This paper systematically elucidates the molecular mechanisms by which iron, manganese, zinc, copper, magnesium, cobalt, nickel…
J Leukoc Biol. 2026 Sep 15:qiag128. doi: 10.1093/jleuko/qiag128. Online ahead of print. ABSTRACT Obesity is a chronic inflammatory disease associated with an increased risk of various medical complications, including cardiovascular problems, diabetes, and infectious diseases. A central element of the immune system associated with inflammation and antimicrobial function is neutrophils. Recently, distinct neutrophil subpopulations have … Read more
Cancer Immunol Res. 2026 Sep 15. doi: 10.1158/2326-6066.CIR-25-1567. Online ahead of print. ABSTRACT Cancer progression following an initial response to immunotherapy (secondary resistance; 2°R) is a major and poorly understood problem. We treated mice bearing B16 melanoma with a combination of a regulatory T cell (Treg) depleting, non-IL-2 blocking antibody (anti-CD25NIB) and an autologous cancer … Read more
J Immunol. 2026 Aug 29;215(9):vkag247. doi: 10.1093/jimmun/vkag247. ABSTRACT SWI/SNF chromatin remodeling complexes regulate gene expression during development and differentiation. These complexes exist in distinct forms, including the polybromo-associated BAF (PBAF) complex, defined by the ARID2 subunit. ARID2 is frequently mutated in B cell leukemias, but its role in normal B cell development remains unknown. Using … Read more
