Publicaciones
CD80 on skin stem cells promotes local expansion of regulatory T cells upon injury to orchestrate repair within an inflammatory environment
In skin injury, the inflammatory environment can impact repair mediated by skin stem cells. Luan, Truong, Vuchkovska, et al. show that hair follicle stem cells migrate into the wound, activate immune-modulatory molecules, and expand extrathymic regulat…
Transcription factor Tox2 is required for metabolic adaptation and tissue residency of ILC3 in the gut
Group 3 innate lymphoid cells (ILC3) play critical roles in gut homeostasis. Das et al. show that transcription factor Tox2 is required by ILC3 to metabolically adapt to the gut environment. They identify interleukin (IL)-17 as an important signal that…
Noncanonical inflammasome mediates BBB breakdown
Nature Reviews Immunology, Published online: 26 April 2024; doi:10.1038/s41577-024-01039-zWei et al. report a role for membrane perforation mediated by gasdermin D pores in disruption of the blood–brain barrier.
FAS signalling pathway is crucial for CAR T cell persistence
Nature Reviews Immunology, Published online: 26 April 2024; doi:10.1038/s41577-024-01038-0A preprint by Yi et al. shows a role for the FAS signalling pathway in controlling the persistence of CAR-modified lymphocytes.
Up-regulated PLA2G10 in cancer impairs T cell infiltration to dampen immunity
Science Immunology, Volume 9, Issue 94, April 2024.
Targeted depletion of PD-1–expressing cells induces immune tolerance through peripheral clonal deletion
Science Immunology, Volume 9, Issue 94, April 2024.
Neonatal and maternal upregulation of antileukoproteinase in horses
IntroductionThe end of gestation, ensuing parturition, and the neonatal period represent highly dynamic phases for immunological changes in both mother and offspring. The regulation of innate immune cells at the maternal-fetal interface during late ter…
Research progress on the role of macrophages in acne and regulation by natural plant products
Acne vulgaris is one of the most common skin diseases. The current understanding of acne primarily revolves around inflammatory responses, sebum metabolism disorders, aberrant hormone and receptor expression, colonization by Cutibacterium acnes, and ab…
Prognostic implications of STK11 with different mutation status and its relationship with tumor-infiltrating immune cells in non-small cell lung cancer
BackgroundMutations in STK11 (STK11Mut) gene may present a negative impact on survival in Non-small Cell Lung Cancer (NSCLC) patients, however, its relationship with immune related genes remains unclear. This study is to unveil whether overexpressed- a…