Publicaciones

The light side of mast cell degranulation: delivering macrophage repair through molecular condensates​Alejandro Schcolnik-Cabrera on 15 de September de 2026 at 10:00

by

J Leukoc Biol. 2026 Sep 15:qiag125. doi: 10.1093/jleuko/qiag125. Online ahead of print. ABSTRACT Mast cell (MC) degranulation is commonly viewed as the rapid release of preformed inflammatory mediators into the extracellular environment. In a recent study published in the Journal of Experimental Medicine, Salm et al. described a more spatially controlled form of MC communication … Read more

Spatially instructed checkpoints in antitumor NK cell immunity. Ruifeng Wang

by

Trends Immunol. 2026 Sep 14:S1471-4906(26)00228-0. doi: 10.1016/j.it.2026.08.012. Online ahead of print. ABSTRACT Natural killer (NK) cell immunotherapies remain less effective in solid tumors than in hematologic malignancies. Poor infiltration, checkpoint engagement, and metabolic stress contribute, but these mechanisms often operate within spatially organized niches. We develop the concept of spatially instructed checkpoints: inhibitory programs locally … Read more

Impaired antigen clearance of macrophages associates with heart failure and non-obstructive azoospermia: insights from transcriptomics, in silico knockout, and in vitro validation

by

BackgroundHeart failure (HF) and non-obstructive azoospermia (NOA) are high-burden diseases that share chronic inflammation and tissue injury. Macrophages are key regulators in both conditions, yet whether a common molecular basis exists remains unclea…

From disease to syndrome pattern: a study on the differentiation of traditional Chinese medicine syndrome patterns in asthma using multi-omics characterization

by

BackgroundBronchial asthma is a highly heterogeneous chronic inflammatory airway disorder. Syndrome differentiation-guided Traditional Chinese Medicine (TCM) treatment for asthma delivers distinct advantages, including fewer adverse reactions and super…

Impact of ALC Nadir and EDRIC on survival outcomes in limited-stage small cell lung cancer receiving chemoradiotherapy: a retrospective analysis comparing twice-daily and once-daily radiotherapy

by

BackgroundThis study aimed to evaluate the prognostic value of absolute lymphocyte count (ALC) nadir and estimated dose of radiation to immune cells (EDRIC) in patients with limited-stage small cell lung cancer (LS-SCLC).MethodsThis study analyzed 288 …

Innate immune dysregulation in celiac disease and refractory celiac disease: mechanisms, management and emerging therapies

by

Celiac disease is traditionally regarded as T-cell mediated autoimmune disorder driven by gluten-specific adaptive immune responses. In this review, we synthesise recent data showing how epithelial stress, IL-15 driven innate circuits and intraepitheli…

deneme bonusu veren siteler - canlı bahis siteleri - casino siteleri casino siteleri deneme bonusu veren siteler canlı casino siteleri cURL Hatası: Could not resolve host: lkl.dolarkurum.com