As an integral component of Lymphocyte Function-associated Antigen 1 (LFA-1), Integrin α L is crucial for the processes of leukocyte adhesion and migration. It engages in specific interactions with Inter-Cellular Adhesion Molecules (ICAMs), thereby pla…
Cancer immunotherapy has revolutionized cancer treatment over the past decades, offering renewed hope to patients with previously untreatable malignancies. This therapeutic approach could be categorized into three primary strategies: immune checkpoint …
ObjectivesSarcoidosis is a multisystem granulomatous disorder characterized by an oxidative imbalance and inflammatory activation. Paraoxonase-1 (PON1) is a high-density lipoprotein–associated antioxidant enzyme that plays a protective role against oxi…
BackgroundChronic inflammation is increasingly recognized as a fundamental driver of pancreatic ductal adenocarcinoma (PDAC) initiation and progression. Although numerous bioinformatics studies have characterized genetic alterations in PDAC, the key in…
BackgroundThe probiotic L. rhamnosus GG (LGG) elicits immunomodulatory actions facilitating the immune tolerance acquisition in children with cow’s milk allergy (CMA). Emerging data suggest that heat-inactivated LGG postbiotic (LGGp) could improve gut …
BackgroundThis study explored whether integrating innovative immunotherapies targeting costimulatory or co-inhibitory pathways beyond standard PD-1, PD-L1, and CTLA-4 treatments affects hepatic adverse events. We further analyzed liver-related side eff…
One of the most significant risk factors for diseases is aging. Interestingly, some organisms, such as naked mole-rats and most turtles, do not exhibit typical aging-like symptoms or increased mortality as they become older. These aspects indicate that…
The neonatal period is characterized by immunological immaturity, rendering newborns vulnerable to infections at mucosal surfaces such as the oral and gastrointestinal tracts. Breast milk, traditionally recognized for its nutritional and immunological …
Colorectal cancer (CRC) is a highly prevalent and lethal malignancy worldwide, whose development is closely associated with gut microbiota dysbiosis and immune microenvironment imbalance. Interferons (IFNs) serve not only as pivotal cytokines bridging …
Varicella-zoster virus (VZV)-induced hemophagocytic lymphohistiocytosis (HLH) is a rare but fatal complication, particularly in immunocompromised hosts. We present an 11-year-old boy with IgA vasculitis who developed severe VZV-HLH complicated by disse…
