Frontiers in Immunology
Research progress on the role of MZB1 in immune regulation
MZB1 (Marginal Zone B and B1 Cell-Specific Protein), an endoplasmic reticulum-resident protein, has recently garnered significant attention for its role in immune regulation. As a critical modulator within various immune cells, MZB1 influences key proc…
Moving for optimal immunity: the effect of acute high-intensity interval training on phenotype, virus specificity and chemokine receptor expression in human CD8+ T cells
IntroductionPhysical activity induces rapid and selective leukocyte mobilization. Among the most responsive cell types to high-intensity exercise are CD8+ T cells, key effectors of immune defense against infected cells and cancer. However, comprehensiv…
The gut-lung axis in severe pneumonia-related lung injury: mechanisms and therapeutic strategies
Severe pneumonia-related lung injury is a life-threatening condition associated with high morbidity and mortality. Recent advances in research on the gut-lung axis have provided novel insights into its pathophysiology and revealed potential therapeutic…
Ginkgo biloba extract suppresses hepatocellular carcinoma progression by inhibiting the recruitment of myeloid-derived suppressor cells through reduced CXCL1 secretion via SRC downregulation
BackgroundHepatocellular carcinoma (HCC) remains one of the leading causes of cancer-related mortality worldwide, characterized by poor prognosis and limited therapeutic efficacy. Ginkgo biloba extract (GBE) has demonstrated antitumor potential, yet it…
Therapeutic vaccines targeting HPV epitopes in human papillomavirus – positive oropharyngeal cancer: a critical review
Human papillomavirus-positive (HPV+) oropharyngeal squamous cell carcinoma (OPSCC) is a peculiar entity, with distinct patient, tumor, and biological characteristics, and a different prognosis compared to HPV-negative (HPV-) OPSCC. Due to the rising in…
Adjunctive GM-CSF therapy enhances host defense against systemic Candida auris infection in immunosuppressed mice
IntroductionCandida auris is an emerging, multidrug-resistant fungal pathogen associated with high mortality in immunocompromised individuals. Resistance to current antifungal drugs emphasizes the need for new therapeutic approaches. We investigated gr…
Case report: Immune checkpoint inhibitor-induced fulminant diabetic ketoacidosis: a case-based review and considerations for immunotherapy discontinuation
ObjectiveTo report a case of advanced lung adenocarcinoma (LUAD) harboring KRAS p.G12C and TP53 p.R273C mutations. While immune checkpoint inhibitor (ICI) therapy offered remarkable clinical benefits, it concurrently induced a fatal endocrine complicat…
Comprehensive analysis of IGFL1 in colorectal cancer and its promotion of tumour progression via inhibition of lipophagy
ObjectiveColorectal cancer (CRC) ranks among the most prevalent malignancies, with increasing incidence and mortality rates presenting a substantial public health challenge. While insulin growth factor like family member 1 (IGFL1) has been implicated i…
Glypican 3-targeted chimeric antigen receptor T cells secreting TROP2-directed bispecific T cell engagers exhibit potent efficacy against lung squamous cell carcinoma
BackgroundChimeric antigen receptor T cell (CAR-T) therapy faces multiple challenges in solid tumors, especially the heterogeneity of tumor antigens. Glypican-3 (GPC3) and trophoblast cell-surface antigen 2 (TROP2) are highly expressed antigens in lung…