BackgroundLong-term antigen-specific data in PMN among Chinese populations remain limited. This study evaluated six target antigens and their clinical significance during extended follow-up.MethodsWe retrospectively analyzed 132 treatment-naïve PMN pat…
The periodontium hosts diverse populations of mesenchymal stem and progenitor cells that are essential for maintaining homeostasis and driving regeneration. These include cells derived from the periodontal ligament, gingiva, and apical papilla. In heal…
BackgroundThe neuroimmune axis plays a crucial role in maintaining pulmonary homeostasis and influencing disease outcomes. Although significant progress has been made in this interdisciplinary field, the research remains scattered, and a unified unders…
Uric acid has complex bidirectional effects on human physiology and disease, influenced by its antioxidant capacity, metabolic regulatory roles, and pro-inflammatory properties, all of which are highly context-dependent. In this review, we synthesize r…
IntroductionNeuropsychiatric systemic lupus erythematosus (NPSLE) is a major clinical challenge, characterized by heterogeneous manifestations and the absence of reliable biomarkers. The mechanisms linking systemic autoimmunity to neuronal injury and n…
We report an invasive deep-tissue infection caused by Neoscytalidium dimidiatum in a diabetic patient in China. Although typically a phytopathogen restricted to superficial human infections, it caused rapid necrosis necessitating hallux amputation. Thi…
BackgroundImmune dysregulation, classified as distinct phenotypes within inborn errors of immunity (IEIs) and collectively known as primary immune regulatory disorders (PIRD) is increasingly recognized as a major contributor to morbidity; however, the …
BackgroundIntracranial germ cell tumors (iGCTs) are categorized into germinomas (GEs) and non-germinomatous germ cell tumors (NGGCTs), which show divergent clinical outcomes with GEs having a significantly more favorable prognosis. This prognostic disp…
BackgroundSpinal cord injury (SCI) is a debilitating neurological condition that results in severe motor, sensory, and autonomic dysfunction, imposing a considerable burden on affected individuals and healthcare systems. Neutrophil extracellular traps …
