Most patients with cancer are older adults living with several other chronic illnesses, and both the tumour and its commonest companions—cardiometabolic disease, type 2 diabetes and depression—are sustained by a shared, immunosuppressive inflammatory m…
Live eukaryotic cells produce extracellular vesicles (EVs) that play a crucial role in cell-to-cell communication and transport various cargoes, including proteins, nucleic acids, and lipids. Based on their biogenesis, size, content, and pathways, EVs …
Pyruvate kinase deficiency (PKD) is a rare autosomal recessive inherited hemolytic anemia caused by pathogenic variants in the PKLR gene. The disease exhibits marked clinical heterogeneity, ranging from compensated anemia to severe transfusion-dependen…
Characterizing kidney disease is challenged by marked cellular heterogeneity and limited tissue availability from renal biopsies. Conventional diagnostic workflows rely on multiple serial sections for parallel staining, increasing tissue consumption, s…
IntroductionAcute promyelocytic leukemia (APL) is defined by its genetics, yet interphase fluorescence in situ hybridization (FISH) for the PML::RARA fusion, the chromosomal complement seen on a metaphase spread, and the marrow’s cellular composition o…
IntroductionThe aim of this study was to evaluate the effect of preoperative immunonutrition (IMN) on oxidative stress parameters and inflammatory cytokine concentrations in patients with pancreatic ductal adenocarcinoma (PDAC) undergoing surgical rese…
Acute myocarditis is a non-ischemic cardiomyopathy with rapid onset and high mortality. Immunometabolic reprogramming of macrophages is a key pathological feature. However the understanding of its mechanisms remains to be clarified. In this study, we f…
Bullous pemphigoid (BP) is a chronic autoimmune blistering disease predominantly affecting the elderly, with conventional immunosuppressive treatments often limited by insufficient efficacy and severe adverse effects. Emerging targeted therapies offer …
Major histocompatibility complex class II (MHC-II) deficiency is a rare autosomal recessive combined immunodeficiency caused by defects in transcriptional regulators controlling HLA class II expression. The disorder is more prevalent in North Africa du…
