BackgroundBile acids are shown to participate in inflammatory responses. This study was designed to investigate the functions of bile acid metabolism-associated genes (BAMGs) in ulcerative colitis (UC), identify the potential biomarkers based on eleven…
BackgroundCommon variable immunodeficiency (CVID) is the most common clinically significant primary antibody deficiency in adults, characterized by impaired immunoglobulin production and recurrent infections. Endocrinopathies represent a substantial bu…
Severe asthma remains a major clinical challenge despite substantial advances in biologic therapies targeting type 2 inflammation. Whereas type 2-high asthma is increasingly well characterized and effectively treated, a considerable proportion of patie…
BackgroundThe impact of donor age on outcomes after allogeneic hematopoietic stem cell transplantation (allo-HSCT) for aplastic anemia (AA) remains poorly defined. The prognostic value of donor–recipient age difference (DRAD) has rarely been explored.O…
Influenza vaccine effectiveness exhibits significant heterogeneity across age groups, largely shaped by lifelong immune remodeling. This review adopts a continuous spectrum perspective-spanning immune development, immune maturation, and immunosenescenc…
ObjectiveAcute severe ulcerative colitis (ASUC) is a life-threatening condition, and biologic-refractory patients may ultimately require surgery. The clinical role of individualised integrative management including traditional Chinese medicine (TCM) in…
Tumor microenvironment-resident immunosuppressive cells-comprising myeloid-derived suppressor cells, regulatory T cells, and tumor-associated macrophages-constitute primary obstacles to effective cancer immunotherapy. Advances in single-cell and spatia…
BackgroundS-ketamine, a widely used clinical analgesic drug and also employed as a therapeutic regimen in cancer pain management, but whether S-ketamine influence on effector immune cells when conquering tumor cells remains unclear.MethodsIn this study…
Interferon-induced transmembrane proteins (IFITMs) are small interferon-stimulated membrane proteins that can limit viral entry, but their effects depend on the virus, entry route, and experimental context. This Mini Review focuses on IFITM3 at the vir…
Multi pathogen vaccines have emerged as a promising strategy to improve vaccine coverage, simplify immunization logistics, and address overlapping global health threats. However, few vaccine platforms have demonstrated robust and durable immune respons…
