IntroductionSystemic sclerosis (SSc) is a heterogeneous autoimmune disease characterized by a paucity of reliable biomarkers for accurate diagnosis and subtype stratification. The considerable clinical variability between diffuse and limited cutaneous …
BackgroundImmune checkpoint inhibitor (ICI)-related cardiovascular toxicity is associated with high mortality, and prediction models may facilitate its prevention and management. However, the predictive performance, quality, risk of bias, and applicabi…
Diabetes mellitus and its complications are chronic inflammatory diseases driven by metabolic stress. PANoptosis is a recently defined inflammatory lytic cell death pathway that integrates key features of pyroptosis, apoptosis, and necroptosis, and is …
BackgroundHead and neck squamous cell carcinoma (HNSCC) faces challenges with limited immune checkpoint inhibitors (ICIs) efficacy. This study identifies NLRX1, highly expressed in HNSCC tumor cells, as a key driver of immune evasion and ICIs’ resistan…
Background and purposeAseptic meningitis (AM) and meningoencephalitis (ME) is a rare and under recognized complication of histiocytic necrotizing lymphadenitis (HNL) in children, with no large-scale series reported. The present study aims to characteri…
Sideroblastic Anemia with B-cell Immunodeficiency, Periodic Fever and Developmental Delay (SIFD) is a rare autosomal recessive disorder caused by biallelic pathogenic variants in the TRNT1 gene, encoding tRNA nucleotidyltransferase 1, an enzyme essenti…
BackgroundpAc/Emm55 (IFx-Hu2.0) is a plasmid DNA therapy encoding a Streptococcus pyogenes-derived bacterial gene. It shows anti-tumor activity in preclinical models, but the mechanisms of anti-melanoma immunity and additive effects with immune checkpo…
BackgroundThe World Health Organization (WHO) classification system, comprising dengue fever (DF), dengue with warning signs (DWS), and severe dengue (SD), has been widely adopted globally; however, clinical management remains challenging. Current warn…
BackgroundWith the widespread application of neoadjuvant immunochemotherapy (nICT) in locally advanced resectable esophageal squamous cell carcinoma (ESCC), determining the optimal postoperative adjuvant treatment strategy has become a critical clinica…
BackgroundPeople living with human immunodeficiency virus (HIV) may develop Graves’ disease as a delayed autoimmune manifestation of immune reconstitution inflammatory syndrome following antiretroviral therapy. Thyroid eye disease (TED) is uncommon in …
