ObjectivePatients with systemic lupus erythematosus (SLE) exhibit heterogeneous renal courses after acute kidney injury (AKI). This study applied latent class mixed modeling to identify AKI trajectory phenotypes in SLE, developed a risk-stratification …
Older adults with comparable bone mineral density or fracture-risk estimates may nevertheless differ markedly in fracture occurrence, repair kinetics and functional recovery. This heterogeneity suggests that skeletal fragility reflects, at least in par…
IntroductionCD40L (CD154) is a homotrimeric member of the TNF superfamily protein expressed on activated CD4+ T cells whose interaction with CD40 is required for class-switch recombination, somatic hypermutation, and B cell terminal differentiation. Lo…
Vitamin C (VC) is an essential micronutrient involved in diverse biological processes, including redox homeostasis, energy metabolism, collagen synthesis, epigenetic regulation, and immune modulation. Increasing evidence indicates that VC plays importa…
BackgroundPost-transplant malignancies (PTMs) remain major late immune-related complications after kidney transplantation, but long-term Asian data integrating immunologic exposures are limited.MethodsWe retrospectively analyzed 1,808 kidney transplant…
Intestinal stem cells (ISCs) are essential for maintaining epithelial homeostasis and tissue repair. Traditionally considered passive regenerative cells, ISCs are now recognized as active environmental sensing hubs that integrate microbial, immune, met…
BackgroundWhile immune checkpoint inhibitors (ICIs) have revolutionized first-line treatment for advanced gastric and gastroesophageal junction (GEJ) adenocarcinoma, outcomes across phase III trials remained heterogeneous. This study aimed to determine…
Persistent inflammation, immunosuppression, and catabolism syndrome (PICS) has emerged as an important contributor to long-term morbidity among survivors of sepsis. This syndrome is characterized by sustained immune dysregulation, metabolic disturbance…
BackgroundUterine corpus endometrial carcinoma (UCEC) is one of the most common gynecological malignancies, and its progression is closely associated with dysregulated protein homeostasis and metabolic reprogramming. TRIM21 is an E3 ubiquitin ligase im…
