Evolocumab in the treatment of refractory chylothorax induced by systemic lupus erythematosus complicated with hyperlipidemia: a case report and literature review

Recurrent chylothorax induced by thoracic duct injury in patients complicated with mixed hyperlipidemia secondary to systemic lupus erythematosus (SLE) is rarely encountered in clinical practice. A 55-year-old female patient diagnosed with SLE, whose p…

Development and preliminary evaluation of a ΔtssB-EP as a live attenuated vaccine against Edwardsiella piscicida

BackgroundVaccination is the most effective strategy for preventing and controlling infectious diseases in aquaculture. Edwardsiella piscicida, a Gram-negative facultative intercellular bacterial pathogen, is the etiological agent of edwardsiellosis in…

Immunoguided cutaneous regeneration: a theoretical framework linking extracellular matrix, immunity, and skin allografts

Adult human skin healing is predominantly characterized by fibrosis rather than true regeneration, despite the conserved regenerative principles observed in fetal wound healing, liver regeneration, and other biological systems. Historical and contempor…

Single strain versus multi-strain probiotics in aquaculture: comparative impacts on gut microbiota and immune responses in fish and shellfish

Probiotics have gained wide popularity as environmentally sustainable replacement for antibiotics in aquaculture due to their ability to up-regulate the host immune competence and boost disease resistance. However, considerable knowledge is yet to gain…

Resveratrol alleviates functional dyspepsia-like pathology by modulating chemokine- and cytokine-related immune–epithelial signaling in the duodenal mucosa

ObjectiveResveratrol is a dietary polyphenol found in grapes, peanuts, and berries, with reported anti-inflammatory, immunomodulatory, barrier-protective, and microbiota-regulating properties. Functional dyspepsia (FD) is associated with duodenal immun…

Survival benefit and immune-related toxicities after hematopoietic stem cell transplantation in Krabbe disease: a systematic review and meta-analysis

BackgroundKrabbe disease is a rare, rapidly progressive leukodystrophy with high early mortality. Hematopoietic stem cell transplantation (HSCT) is the main disease-modifying intervention used in clinical practice and may act through donor-derived myel…

Distinct phenotypic clusters associated with progressive pulmonary fibrosis in anti-synthetase syndrome-associated interstitial lung disease

BackgroundThe clinical manifestations of anti-synthetase syndrome-associated interstitial lung disease (ASyS-ILD) are highly heterogeneous, and the mechanisms underlying its development and progression remain poorly understood. This study aimed to iden…

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