IntroductionLymphedema, a progressive condition involving unresolved swelling and inflammation, affects as many as 1 in 1000 Americans. Although CD4+ T cells are implicated in the chronic inflammatory process, antigen-specific responses are understudie…
Autoimmunity arises when the immune system erroneously attacks self-antigens, potentially resulting in organ dysfunction. This review focuses on the proliferation-inducing ligand, APRIL, and its critical role in regulating antibody-producing B cells. W…
Immunoglobulin Fc receptors are crucial molecules in immunological processes that help maintain homeostasis following internal or external stimuli. Most of the specific gamma recognition molecules (FcγRI, II, and III) are known for their roles in phago…
The interplay between the gut microbiota, bile acid (BA) metabolism, and the tumor immune microenvironment (TIME) is a critical and rapidly advancing field in cancer immunology. Microbiota-transformed bile acids act as pivotal signaling molecules. This…
Chimeric antigen receptor (CAR) T cells are a transformative treatment for hematological malignancies, and concerted efforts in the field are aiming to translate this success to solid tumors and autoimmune diseases. There is a desire in the field to ac…
J Leukoc Biol. 2025 Jul 31:qiaf111. doi: 10.1093/jleuko/qiaf111. Online ahead of print. ABSTRACT Morphologic studies show increased mast cell activation during T cell-mediated inflammation. Previous research demonstrated that microvesicles from activated T cells (MVT*), but not resting T cells (MVT), stimulate human mast cells via the MAPK pathway, leading to degranulation and cytokine release. This … Read more
J Leukoc Biol. 2025 Jul 31:qiaf110. doi: 10.1093/jleuko/qiaf110. Online ahead of print. ABSTRACT Psoriasis is a systemic inflammatory skin disorder with a prevalence of 2 % in adults. Up to 30 % of affected individuals further develop psoriatic arthritis (PsA), which is characterized by additional joint inflammation. Myeloperoxidase (MPO) is strongly expressed by neutrophils and, … Read more
Cancer Immunol Res. 2025 Jul 31. doi: 10.1158/2326-6066.CIR-24-0534. Online ahead of print. ABSTRACT Pancreatic adenocarcinoma (PDAC) has a dismal survival rate due to limited effective therapies. While studies have focused on innate immune cell influence on adaptive immune cell functions, few have explored interactions between innate immune cells, which modulate the unique PDAC tumor microenvironment … Read more
Cancer Immunol Res. 2025 Jul 31. doi: 10.1158/2326-6066.CIR-24-0853. Online ahead of print. ABSTRACT Despite the effectiveness of anti-programmed death 1 (PD-1)/PD-1 ligand 1 monoclonal antibodies against various cancers, resistance remains a significant issue among patients. The immunosuppressive T cell immunoreceptor with Ig and ITIM domains (TIGIT)/CD155 axis has emerged as a key mechanism contributing to … Read more
J Immunol. 2025 Jul 1;214(7):1439-1440. doi: 10.1093/jimmun/vkaf145. NO ABSTRACT PMID:40740035 | DOI:10.1093/jimmun/vkaf145
