Background
The peritumoral microenvironment has emerged as a key role in affecting tumor invasion and immunotherapy responses. In adipose-enriched tumors, such as breast cancer (BC), peritumoral adipose tissue (PA) harbors unconventional immune popula…
Background
Chimeric antigen receptor (CAR) macrophage therapy shows significant potential for solid tumors owing to the intrinsic tumor infiltration and phagocytic capacity of macrophages. However, its clinical translation is limited by macrophage phe…
Curr Opin Immunol. 2026 Jul 27;102:102831. doi: 10.1016/j.coi.2026.102831. Online ahead of print. ABSTRACT Cardiac sarcoidosis is a potentially fatal inflammatory disorder with the tendency to mostly affect the myocardial tissues. It is commonly associated with extra-cardiac structures such as the lungs and the thoracic lymph nodes; however, when it manifests as an isolated disease, it … Read more
Current models of microbiome, immune crosstalk center on extracellular receptor-mediated signaling, yet a critical observation challenges this paradigm: intracellular concentrations of gut-derived bacterial metabolites (GDBMs) in CD4+ T cells do not co…
BackgroundVascularized composite allotransplantation (VCA) has emerged as a reconstructive option for complex tissue defects, yet its oncologic long-term safety remains poorly characterized.AimsThis study aims to provide the most comprehensive overview…
Highly sensitized kidney transplant candidates face major barriers to transplantation because broad anti-HLA antibody reactivity substantially limits donor compatibility. We conducted a retrospective cohort study comparing two allocation eras in Pernam…
BackgroundAging drives metabolic decline and the accumulation of senescent cells that evade immune clearance. The mechanisms linking host-microbiome co-metabolism to peripheral tissue deterioration remain unclear. We hypothesized that age-dysregulated …
Osteoarthritis (OA) is a complex degenerative disease centered on inflammation and involving multi−cellular cooperation, with a continuously rising global burden. Current therapeutic measures mainly focus on symptom relief, slowing progression, and end…
Immunotherapy has redefined oncology, yet its efficacy remains constrained by low response rates, primary or acquired resistance, immune-related toxicities, and escalating costs. Bacteria-mediated cancer immunotherapy (BCIT), which exploits the intratu…
